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KMID : 0369819920220010033
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Jorunal of Korean Pharmaceutical Sciences
1992 Volume.22 No. 1 p.33 ~ p.40
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Preparation and Controlled Release of Microcapsules Containing Ketoprofen - β - Cyclodextrin Solid Dispersion
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전인구/Chun IK
박정화/Park JH
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Abstract
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This study was aimed to control the release characteristics of ketoprofen by microencapsulating ketoprofen-β-cyclodextrin (KF-β-CyD) solid dispersion with Eudragit RS by the phase separation method using a nonaqueous vehicle. KF alone was also microencapsulated with Eudragit RS by the evaporation process in water phase. The results obtained showed that it was not possible to microencapsulate KF alone by phase separation in a chloroform-cyclohexane system while it was easy to microencapsulate KF-β-CyD solid dispersion system. For the microcapsules, the release test was performed in the first fluid (pH 1.2) and the second fluid (pH 6.8) of K.P.V disintegration medium at 37℃. The release of KF from KF-β-CyD solid dispersion microcapsules (1:1 core wall ratio) was more sustained than that from KF microcapsules, and followed zero-order kinetics. Especially, solid dispersion microcapsules showed pH-independent release patterns with higher wall to core ratio (1:1 w/w).
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